T cell repertoire changes predictive of anti-CTLA-4 cancer immunotherapy outcome

A recent study that investigates the effects of anti-CTLA-4 antibody on the number and types of T cells present in a patient’s blood. The results, which appear in the journal Science Translational Medicine, shed light on the mechanism of action of this type of cancer immunotherapy and suggest that immune repertoire sequencing could be used to predict which patients will have improved survival in response to treatment.Continue reading